Santa Rosa, NM Hotel's on Historic Route 66 Tucked away in eastern New Mexico and surrounded by the flat, desert landscape, Santa Rosa stands as an oasis to travelers exiting Interstate 40. Our hotel's location in the "City of Natural Lakes" offers convenient access to the refreshing Blue Hole, the area's rich history and local industries. From eating at neon-lit diners to viewing the Route 66 Auto Museum's vintage cars, you can get lost in the golden era of America's most-famous highway right off Interstate 40. Our hotel's location in Santa Rosa, New Mexico also puts you near the famous Blue Hole diving well, the waterslide at Park Lake and the Santa Rosa Softball Complex. Head eight miles south to explore the adobe village of Puerto de Luna, a favorite stop of Billy the Kid. Business travelers can find respite at the Holiday Inn Express® Hotel in Santa Rosa, NM. Our hotel's address puts you minutes from Guadalupe County Hospital, Santa Rosa Convention Center and the area's major industries: medical, natural gas and alternative energy. We offer free wired and wireless Internet access in all rooms and in the Business Center off our hotel's lobby. While in Santa Rosa, New Mexico, you'll enjoy Southwestern hospitality and a helpful staff at our hotel. Start each day with the free, hot Express Start Breakfast Bar. Stay active during your trip with a workout in the Fitness Center, and then relax in the indoor, heated pool and whirlpool.