Welcome to One of the Best Hotels in Santa Maria, CA Located on El Camino Real between the beautiful cities of San Luis Obispo and Santa Barbara, Santa Maria is a place where fresh produce, local wineries and a Mediterranean climate combine to create a wonderful atmosphere. No matter what brings you to this California city, you're sure to enjoy your trip. At the Holiday Inn® & Suites Santa Maria you are near Vandenberg Air Force Base, as well as area companies, including Lockheed Martin, Boeing, Denmat, Raytheon and Babe Farms. We have a 24-hour business center and more than 1,800 sq. ft. of event space. When it comes to leisure activities, there are plenty of options near our hotel. Santa Maria is home to recreation areas like Guadalupe-Nipomo Dunes, historic attractions such as La Purisima Mission and Santa Maria Museum of Flight. The Foxen Canyon Wine Trail features favorite, boutique wineries, including Cambria, Fess Parker, Firestone and Kenneth Volk, and it is a great way to spend a day exploring the area. If you prefer non-alcoholic activities or are traveling with children, play a round of golf at one of the many courses or visit the Santa Maria Valley Children's Discovery Museum. Our Santa Maria, CA hotel's amenities are sure to make your stay a great one, whether you're here to do business or to enjoy the sights. Make your reservations today to enjoy our outdoor pool, whirlpool, fitness center and the Portabella Bar & Grill.