Downtown Palo Alto, California HotelThe historic Cardinal Hotel delivers an elegant, nostalgic atmosphere in culturally diverse Downtown Palo Alto. Our ideal proximity to world-class dining, shopping, arts, attractions and Stanford University, competitive rates and completely smoke free environment make us your perfect destination for business or leisure trips in Northern California. Historic Palo Alto Hotel. Built in 1924, the Cardinal Hotel is Palo Alto's premiere historic lodging with a charming ambiance and the grace and serenity of days past. The gracious lobby still provides a delightful glimpse of Old Palo Alto. Downtown Palo Alto Hotel. Outside our doors, the lively tree-lined streets along University Avenue are home to eclectic cafes, excellent restaurants, unique bookstores, art galleries and boutiques. The hotel is located 1 mile from Stanford University and the Stanford Shopping Center. Silicon Valley Hotel Location. We're easily accessible to Palo Alto and Silicon Valley corporations and businesses, as well as Stanford Medical Center and Stanford Linear Accelerator Center. Bay Area Home Base. Our guests consider the Cardinal Hotel their home away from home, enjoying vintage guest service, comfortable rooms and suites, and convenient high-tech amenities. The Cardinal Hotel is a smoke free property.