Stay Your Way at Our Hotel's Opelousas Locale Welcome to our non-smoking hotel in lovely Opelousas, LA. We are pleased to offer contemporary, attractive pet-free rooms and a quaint location in the heart of South Louisiana's Cajun country. Business and leisure travelers lodging in Opelousas, LA choose our Holiday Inn® address for the best accommodations of all area hotels. In Opelousas, visitors can discover a fascinating trove of history at sites like Arlington Plantation and Le Vieux Village or enjoy more contemporary attractions like Evangeline Downs Racetrack & Casino. Guests lodging in Opelousas, LA are minutes from historic downtown Opelousas shopping, dining and entertainment, as well. With Lafayette just a short ways from our hotel's Opelousas, LA hideaway, you can enjoy the city or escape the hustle and bustle. Business travelers appreciate our hotel's facility in Opelousas, LA for its convenient access to the Lafayette Airport, just 20 miles away, and close proximity to local and corporate businesses. If you're planning an event, opt for our function space, ideal for meetings, conferences and weddings. If you're looking for a place to relax with co-workers, our hotel's location in Opelousas is near golf and tennis facilities. Newly renovated and offering terrific amenities like an indoor swimming pool, free Wi-Fi access and a business center, our pet-free and smoke-free Holiday Inn® hotel is the perfect pick.