Our new O'Fallon, Missouri hotel offers comfort and convenience. The Holiday Inn Express Hotel & Suites in O'Fallon, MO is located just west of St. Louis. Our hotel is convenient to Interstate 40 and I-64 and is near several local attractions and businesses, making it the perfect hotel for travelers looking for lodging in O'Fallon. Conveniently located near major companies such as Citi Corporation, General Motors, Mastercard, APC, Nordyne, the Missouri Research Park and Progress West Hospital, our O'Fallon, MO hotel is ideal for area business travelers. You can take advantage of our meeting room and 24-hour business center, enjoy the convenience of a free local shuttle and stay connected with free high-speed Internet access. Leisure travelers in O'Fallon will enjoy staying at our hotel as they explore everything the St. Louis area has to offer. We are just minutes from historic St. Charles, Six Flags Over Mid-America and the Augusta vineyards. The St. Louis Arch, Anheuser-Busch, Laclede's Landing and the stadiums of the Cardinals and the Rams are just a short drive into St. Louis from our hotel in O'Fallon. During your stay at our pet friendly O'Fallon, Missouri hotel be sure to take advantage of our choice amenities, including a heated, indoor pool and whirlpool, a fitness center and the free Express Start hot breakfast bar featuring our signature cinnamon rolls. Check out our great O'Fallon hotel deals and book your stay today.