A Gracious Hotel in North Charleston, SC Welcomes You The Holiday Inn Express Hotel North Charleston, SC welcomes you to the "friendliest city in the nation". Charleston is the ideal South Carolina vacation destination because it has everything, from deep-sea fishing, world-class golf and tennis, museums and Spoleto. Leisure travelers appreciate our North Charleston hotel's convenient location and access to the city via I-26. Museum Mile, Fort Sumter, Rainbow Row and the historic district are only 18 miles away. Charleston Southern University and Wannamaker is almost next-door. And while lodging in Charleston, SC at our hotel, you can step back in time by visiting nearby plantations. Our low-country accommodations in North Charleston mean business travelers are close to the Charleston Airport (CHS). Our hotel is conveniently located close to Boeing, Palmetto Commerce Parkway, Trident Hospital and Bushy Business Park . The North Charleston Coliseum, Summerville, Goose Creek and Moncks Corner are convenient too. Our hotel is the perfect place for you to start your cruise with our Park and Cruise Package. The Holiday Inn Express Hotel North Charleston is the perfect lodging for everyone from families to groups. Stay Smart on your next visit to Charleston, South Carolina and enjoy great Charleston hotel deals today.