Jamestown Hotel Near I-94 & Buffalo Museum Nestled between the Jamestown Reservoir and a roaming herd of American Bison is the Holiday Inn Express® Hotel Jamestown, ND. This hotel's address is minutes from a number of family-friendly attractions & nearby businesses. If you're looking for business-friendly hotels in Jamestown, North Dakota, look no further. We're near Cargill, Cavendish Farms, Goodrich, Jamestown College, Jamestown Regional Medical Center and PepsiAmericas. We feature a 558-sq-ft meeting room that is great for any business or social event. And we feature free Wi-Fi access. Leisure travelers headed to Jamestown love our hotel for its proximity to nearby attractions, including the World's Largest Buffalo, located at the National Buffalo Museum. You can also visit the historic Frontier Village & a herd of American Bison that includes three rare albino bison. We're also a few minutes from the Arts Center, as well as 30 miles of hiking & biking trails, Jamestown Reservoir & Pipestem Lake. It doesn't matter if business or pleasure brings you to our hotel's accommodations in Jamestown, North Dakota; we have the amenities to satisfy your needs. We keep you connected with free Wi-Fi access and free local calls. Start your day right with the Free Express Start Breakfast Bar, and later, burn calories with our state-of-the-art Fitness Center. If you're planning a vacation in Jamestown, ND, choose our hotel's well-designed rooms.