Welcome to the Holiday Inn® Cape Cod Hyannis Hotel Stylish and contemporary, the Holiday Inn Hyannis provides a wonderful "home away from home", while in the Hyannis area. Nestled in the center of Cape Cod, this Hyannis hotel offers easy access to breathtaking beaches, historic charm, fine dining and entertainment. During any visit to our property in Hyannis, you'll be sure to enjoy our quality amenities and superb service. Visit one of the many area attractions including the JFK Museum, vibrant Main Street, the Hyannis waterfront district and a myriad of beaches. While staying in Hyannis Cape Cod, hotel guests can enjoy taking a short ferry ride to Martha's Vineyard and Nantucket or a day trip to Provincetown and the National Seashore. Just minutes from the Barnstable Municipal Airport, our hotel's address on Iyannough Road is close to the Independence Park commercial district in Hyannis, MA - home to a number of companies including Cape Cod Potato Chips, Cape Air, SSA Global and Intuit. With our 24-hour business center and six spacious meeting rooms, we cover all of your corporate needs. At the Holiday Inn® hotel, you can stay your way. Keep up with your exercise routine at our well equipped fitness center and relax in our heated, indoor pool and whirlpool. Start your day off right with a delicious breakfast in our restaurant and later enjoy dinner and drinks at the Mad Hatter lounge. Make the smart choice and stay at the Holiday Inn Hyannis.