Choose Our Pet-Free Hotel in Hannibal Welcome to the Holiday Inn Express® Hotel & Suites Hannibal located near Highway 61 in "America's Hometown," Hannibal, Missouri. Our hotel's sparkling, clean facility offers the name you trust, the services you deserve and a price to fit your budget. Business travelers appreciate our hotel's great Hannibal location near General Mills, Buckhorn, Enduro and all other factories in the industrial area. We offer corporate amenities like a business center that features copy, fax and print services, as well as free Wi-Fi access. There's also event space available for business seminars or meetings at our hotel. Hannibal business travelers make the smart choice when they choose us. Leisure patrons know that we're a cut above other hotels, with Hannibal city attractions, restaurants and shopping areas just minutes away. Historic downtown boasts the Mark Twain Home and Museum, and other interesting Twain related attractions, like Sawyer's Creek Fun Park, are less than three miles from our hotel. This Hannibal attraction is perfect for the kids and is located right across the street from Mark Twain Cave and Cameron Cave. Our friendly staff offers a 24-hour welcome to Mark Twain's Hometown and to our pet-free Holiday Inn Express® hotel in Hannibal, Missouri. Our hotel's clean facility is proud to offer a free, hot breakfast every morning, our brand new fitness center, an indoor pool and a whirlpool.