Enjoy One of the Best Hotels in Athens, Tennessee Situated just off Interstate 75 halfway between Chattanooga and Knoxville, TN, Athens is a quiet city nestled in the foothills of the Great Smokey Mountains. Whether you're in town for business or leisure, we're sure you'll enjoy "The Friendly City." Need a place to stay for your business trip? The Holiday Inn Express® Athens, TN hotel is a great choice since we're within five miles of companies like Denso Manufacturing, Johnson Controls, ThyssenKrupp and the Mayfield Dairy headquarters. You can also use our Athens, TN hotel's 24-hour Business Center to prepare a presentation. Our 750-square-foot meeting room is great for hosting events, as well. If leisure activities bring you to Athens, TN, our hotel is the perfect jumping-off point to enjoy the surrounding area. Cyclists, bikers and road enthusiasts will appreciate that we're just a short drive from the Cherohala Skyway and the Dragon Back, which boasts more hairpin turns than any other 13-mile stretch of road in the U.S. You can also visit the Lost Sea in Sweetwater, TN and explore the underground lake, go spelunking and then camp overnight inside the cave. No matter what brings you to Athens, TN, our hotel's amenities, including an indoor pool and spa, Fitness Center and free, hot breakfast, are sure to please. Make reservations today to enjoy the Southern hospitality that makes us one of the best hotels in Athens, Tennessee.