Hotel in Amarillo, Texas Offers Ideal Location New in 2008, the Holiday Inn Express® Amarillo South hotel offers modern conveniences with upscale amenities. Located of I-27, this hotel is the perfect choice for business and leisure travelers visiting Amarillo, Texas. Our hotel's location near many area businesses is ideal for traveling professionals. Guests can enjoy quick access to companies like Bell Helicopter, Blue Cross Blue Shield, Owens Corning, Cactus Feeders and Texas Tech School of Pharmacy and Medicine. We are also close to local medical centers like the VA Medical Center, Northwest Texas Health Care System and Texas Panhandle MHMR. If you are visiting Amarillo for pleasure, our hotel's I-27 location will make it easy for you to see all the popular area attractions. We are just a few miles from sites like Cadillac Ranch, Panhandle-Plains Historical Museum, Palo Duro Canyon State Park and Amarillo Botanical Gardens. Our hotel is also just a short drive to the great shopping and dining opportunities along the part of Historic Route 66 that runs through Amarillo, Texas. This hotel's location is just one of the many reasons you will enjoy your stay. We offer great on-site amenities like free high-speed Internet access, a 24-hour Business Center, a complimentary hot breakfast bar and an indoor pool and whirlpool. Come experience our famous Texas hospitality at the Holiday Inn Express® hotel in Amarillo, Texas.