Experience One of the Best Costa Mesa, California Hotels Centrally located among beautiful beaches, fine dining, premier entertainment and exclusive shopping, our Costa Mesa, California hotel's accommodations are convenient and comfortable. In addition, our Holiday Inn Express® Costa Mesa is just over two miles from the John Wayne International Airport and easily accessible from the 405 and 55 Freeways, making travel a breeze. Business travelers at our hotel's location in Costa Mesa, CA certainly appreciate our well-equipped business center with fax, e-mail, copy and print services. Hoag Hospital and the University of California-Irvine are only minutes from the hotel. Guests are encouraged to spend the day enjoying the sun and sand at Newport Beach or strolling along the streets of Balboa Island when staying in Costa Mesa, California. Our hotel's guests can take advantage of shopping at the South Coast Plaza and even take the family to Disneyland® for the day since it's just a short drive away. No matter your entertainment preferences, there's something for everyone. Our extra amenities are what truly set us apart from other hotels in Costa Mesa, CA. Grab a fresh baked cookie on your way in or out of the hotel and be sure to stop in before a day of sightseeing and enjoy our complimentary hot breakfast buffet. In addition, we provide complimentary day passes for our guests to use the facilities at 24 hour fitness Costa Mesa.