Hotel's Address in Sikeston, MO Near I-55 Large, illuminating windows and contemporary decor welcome you to the Holiday Inn Express® Sikeston. Our hotel's address in Sikeston, MO surrounds you with fun attractions. Thanks to a convenient location near I-55 and nearby companies, business travelers are drawn to our hotel. Sikeston, MO is home to a variety of companies, including John Deere, Monsanto, Orgill, Tyson Foods and Unilever. In addition, we provide guests with a selection of handy services at our state-of-the-art business center. Experience the charm of Sikeston with our hotel's proximity to attractions like Lambert's Cafe, an eatery that's famous for throwing tasty rolls to customers. Sikeston is also home to the annual Sikeston Jaycee Bootheel Rodeo, which draws large crowds every August. Our accommodations are near the home venue of the Sikeston Bulls and two 18-hole golf courses, as well as the twenty or more shops at Sikeston Factory Outlet Mall. Whether you're staying at our hotel in Sikeston, MO for business or pleasure, we have the amenities to satisfy your needs. Connecting to colleagues and family is easy with the free high-speed, Wi-Fi access, and mornings are great with a cup of coffee and gooey cinnamon roll from our free, hot Express Start breakfast bar. Go for a dip in the indoor pool or burn calories in our state-of-the-art fitness center. If you're looking for lodging in Sikeston, our hotel's the smart choice.